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The research in DENAMIC consists of two distinct pillars:
Hazard characterization
Exposure/epidemiology
The first pillar involves hazard characterisation for neurotoxic chemicals and (environmentally relevant) mixtures thereof. Novel tools, testing methods and procedures for screening (mixtures of) chemicals for neurotoxicity are developed, together with improved assessment methods for exposure and effects.
In the second pillar (exposure/epidemiology), perinatal and early-childhood exposure will be studied in maternal urine and cord blood, as well as breast milk and urine of the child. In the epidemiological part these developed integrated tools are tested in a tailor made cohort of mother/child pairs focusing on learning and developmental disorders, including the onset of ADHD. In both the experimental and epidemiological part of DENAMIC, biomarkers for developmental neurotoxicity will be developed and/or validated by using innovative biotechnology tools.
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